Strike Force Currandooley was established last month in the district to investigate the supply of methylamphetamine in Griffith, Leeton and Narrandera.

At about 11am on Tuesday, strike force detectives arrested three men, aged 48, 49 and 54 during a vehicle stop on Brobenah Road Leeton.

The men were taken to Griffith Police Station.

Following the arrests, detectives executed two search warrants at Narrandera homes and another search warrant at a home in Griffith, assisted by the Dog Unit, Public Order Riot Squad, Operational Support Group and the Rural Crime Prevention Team.

Two men, aged 39 and 43, were arrested at Narrandera and taken to the local police station.

During the searches, the drug 'ice', cannabis and cash were seized.

The 39-year-old man was charged with supplying a commercial quantity of a prohibited drug.

The 43-year-old man was charged with two counts of supplying a prohibited drug and will face court today along with the 39-year-old man in Wagga after being refused bail.

The 49-year-old man was charged with supplying a prohibited drug and the 48-year-old man was charged with two counts of supplying a prohibited drug.

Those two men were refused bail to appear in Griffith Local Court today.

The 54-year-old man was charged with knowingly taking part in the supply of a prohibited drug and was granted conditional bail to appear at Griffith Local Court on January 13 2021.

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Murrumbidgee Police District Commander Superintendent Craig Ireland said these arrests came from a month of investigations by the strike force.

"The hard work and dedication of our officers has led to the arrest and charge of five people for drug offences," he said.

"Ice is a poison and it has the potential to destroy communities - I want to reinforce the message that supplying drugs will not be tolerated in our community.

"We will continue to dismantle criminal networks operating in our region, even if we have to do it one by one."

Inquiries are continuing.